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Finasteride drug group, we found significantly lower serum 25[OH]D levels among individuals receiving the 5α-reductase inhibitor dutasteride (5 ng/ml: −11.4; CI: −18.0, −4.7; 95% −22.8, 0.0 ng/ml: −12.6 canada pharmacy phone number and −19.9; 95% CI: −22.9, 2.2 ng/ml) compared with placebo (1.7 nM; 95% CI: 1.7, 1.9 nM). In addition, there was a dose-dependent decrease in 25[OH]D response to dutasteride (see Supplemental Figure 1 under "Supplemental data" in the online issue). Analyses of total and specific 25(OH)D serum levels indicated significant decreases in patients treated with dutasteride (5 ng/ml: −2.8 and −25.9, respectively; P < 0.001). There was a trend toward an increase in 25(OH)D levels individual patients with subnormal 25(OH)D levels (see Figure 1A) but there were no statistically significant changes between individual patients. Figure 1 View largeDownload slide Serum concentrations of 25(OH)D at enrollment. A, Serum levels of 25(OH)D on enrollment in the five randomized study groups. Each bar represents means ± 95% CIs of individual data. The median study group is indicated. The horizontal dashed line represents median 25(OH)D level found in one individual each study group at the beginning of each treatment. B, Serum levels of 25(OH)D in the dutasteride group at enrollment during the study. Each bar represents median and individual data. The vertical dashed line represents median 25(OH)D level found in two individuals each study group at the beginning of each treatment. *P < 0.05, **P 0.01, ***P 0.001 versus placebo. Figure 1 View largeDownload slide Serum concentrations of 25(OH)D at enrollment. A, Serum levels of 25(OH)D on enrollment in the five randomized study groups. Each bar represents means ± 95% CIs of individual data. The median study group is indicated. The horizontal dashed line represents median 25(OH)D level found in one individual each study group at the beginning of each treatment. B, Serum levels of 25(OH)D in the dutasteride group at enrollment during the study. Each bar represents median and individual data. The vertical dashed line represents median 25(OH)D level found in two individuals each study group at the beginning of each treatment. *P < 0.05, **P 0.01, ***P 0.001 versus placebo. Table 2 Drug Treatment group (n = 20) Randomization Median (range) 25(OH)D, nmol/L n Dose, mg* Median (range) 25(OH)D, nmol/L n Dose, mg* Mean SD 25(OH)D, nmol/L n Dose, mg* Mean SD dutasteride 5 (10) 1.7 (11) 19 (0.3) 0.2 (0.5–0.4) 2.6 (5) 1.7 (11) 5.6 (1.9) 0.1 dutasteride 5 (20) 1.7 20 (0.3) 1.5 (8) 3.9 (9) 1.7 (20) 7.3 (10.6) 1.1 Placebo 5 (20) 1.6 (21)

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